Friday, December 31, 2021

Sorry Everyone, There’s No Real Scientific Evidence That Any Hangover Cure Works

From the hair of the dog to overpriced green smoothies, there’s no shortage of purported tonics for the lingering effects of a night on the sauce. Unfortunately, however, new research suggests that these supposed hangover cures may be nothing more than folk remedies, as there’s no real scientific evidence that any of them actually work.

Appearing in the journal Addiction, the systematic review looks at 21 placebo-controlled trials involving an array of different compounds that are often used to alleviate hangovers. Using a tool called the Grading of Recommendations Assessment Development and Evaluation (GRADE) framework, the authors concluded that all of these trials were of very low quality, and that the evidence they provide cannot be considered robust.

That’s not to say that none of the substances investigated showed promise as hangover cures. On the contrary, clove extract, red ginseng and Korean pear juice were all found to reduce discomfort while hanging. Other compounds that brought about improvements included a type of non-steroidal anti-inflammatory painkiller called tolfenamic acid, a vitamin B6 analog known as pyritinol, and the amino acid L-cysteine.

However, the study authors say that all of the trials included in their review were hindered by “methodological concerns and imprecision”, and that none of these findings are particularly credible. For instance, they point out that most of these trials involved small numbers of participants, while the fact that none of these supposed hangover cures were investigated in more than one study makes it impossible to conduct any sort of meta-analysis.

Furthermore, the studies generally failed to report on key variables such as the type of alcohol used, whether or not this was ingested on an empty stomach, and how much time elapsed before the hangover remedy was administered. A general lack of female representation also detracts from the reliability of any findings, with eight of the 21 studies involving only men. Of the 386 participants across all of these trials, only 38.6 percent were women.

Interestingly, the study authors point out that common painkillers like aspirin or paracetamol have never been investigated as hangover cures in any placebo-controlled trial. Based on these observations, they call for “adequate scientific exploration [of potential hangover cures] in order that practitioners and the public be provided with accurate evidence-based information and do not rely on non-efficacious or potentially harmful interventions.”

Summing up the findings of this review paper, study author Dr Emmert Roberts explained that “evidence on these hangover remedies is of very low quality and there is a need to provide more rigorous assessment. For now, the surest way of preventing hangover symptoms is to abstain from alcohol or drink in moderation.”


Tuesday, December 28, 2021

Immune system can detect disease during pregnancy


 Better understanding of the normal development of a woman's immune system during pregnancy can offer diagnostic possibilities

Pregnancy is a challenge for the mother's immune system from the outset. Half of the genes in the foetus are foreign to her body.

The immune system has to strike a balance between tolerating the foetus and protecting the mother and foetus from infections. Throughout the pregnancy, an immunological balance takes place between mother and child.

At the Norwegian University of Science and Technology's (NTNU) Centre for Molecular Inflammation Research (CEMIR), a research group is engaged in studying inflammation in pregnancy. The group has made findings that shed light on how the immune system behaves during pregnancy.
707 pregnant subjects

Anders Hagen Jarmund, a research programme student, and his colleagues at CEMIR are the first researchers to survey the development of women's immune responses throughout pregnancy.

The study followed 707 women with normal pregnancies, who gave birth to healthy full-term and post-term babies.

“Our immune system is regulated by cell signalling molecules called cytokines. The signalling molecules can trigger or stop immune responses. We profiled a number of different cytokines in the blood using a simple blood sample from the mother. Linking the measurements of lots of cytokines at several points in the pregnancy gave us an imprint of the mother's immune response,” says Jarmund.

“Because we have so many healthy pregnant women in the study, we were able to find the ‘standard’ for how the immune system behaves during normal pregnancies,” he says.
"Standard" pregnancy

Blood samples from the mother provide detailed information about inflammatory conditions in the body, the strain on the foetus and early signs of immunological disorder.

The researchers found that immune activity in normal pregnancies follows a certain pattern, with elevated immune activation in the first three months, then a calmer phase the next three and higher activity in the last three months, especially when childbirth is imminent
Finding abnormalities

Jarmund believes that studying the immune system's behaviour in normal pregnancies can be very useful.

“Our study can serve as a reference for what’s normal at different stages throughout pregnancy. By comparing analyses of blood samples from the pregnant woman with our survey, we can detect abnormalities very early,” Jarmund said.

“Early detection can help the doctor assess whether the woman has an increased risk of developing a disease and needs extra close follow-up.”
Risk factors

Jarmund discovered several conditions in the mother or foetus that created abnormalities in the immune response.

“The immune changes detected with cytokine profiling are so sensitive that they capture the effects of obesity and smoking in the mother. The immune system is also affected if the foetus is stunted, and may even indicate whether it’s a boy or a girl,” says Jarmund.

Another finding was that women who had given birth previously clearly had higher immune activation in the beginning of their pregnancy, but lower than first-time mothers as labour approached. Women who went over term had particularly strong immune activation, which might indicate stress.
Method used for PCOS

Live Marie T. Stokkeland is a PhD candidate at the same centre as Jarmund, as well as at the Women's Health and PCOS group led by Professor Eszter Vanky. Stokkeland is studying a group of women with PCOS (polycystic ovary syndrome).

PCOS is a hormonal disorder characterized by increased levels of male hormones and blisters on the ovaries. About 17 per cent of women of childbearing age are affected.

Women with PCOS often experience irregular menstruation, overweight and increased hair growth on the face and body, and they often struggle to conceive.The risks for women with PCOS during pregnancy include preeclampsia, gestational diabetes and premature birth.
Increased activity in the immune system

Stokkeland analysed blood samples from 358 women with PCOS and a sample group of healthy women.She found that women with the disease have higher immune activation throughout pregnancy than healthy women, and their immune response developed differently during the three phases of pregnancy.Women with PCOS who smoked or were overweight showed even stronger immune activation.

Once we’ve mapped the changes that characterize various pregnancy complications, it will show us which abnormalities we should look for in order to detect disease development as early as possible.

“We believe that the overactive cytokines in pregnant women with PCOS are an unfavourable response that indicates stress, and that may be a contributing factor to an increased risk of complications. We hope that further research will tell us more about the causes of adverse responses and what can be done to prevent them,” says Stokkeland.
Finding high-risk pregnancies

Professor Ann-Charlotte Iversen, who leads the group that is studying inflammation in pregnancy, believes the two studies offer exciting perspectives.

“A cytokine profile is a very sensitive measurement of the immune system, and now we have a better understanding of the immune system’s normal development in pregnancy and how it’s affected,” says Iversen.

“Once we’ve mapped the changes that characterize various pregnancy complications, it will show us which abnormalities we should look for in order to detect disease development as early as possible. Having this sensitive a method will enable us to point out high-risk pregnancies so we can follow up the mother and foetus more closely. That’s our goal,” says Iversen.

The research group at the Department of Clinical and Molecular Medicine does not yet know whether each individual disease generates a unique "fingerprint" in the immune response. So far, the analyses have revealed an abnormal cytokine profile for PCOS and gestational hypertension (high blood pressure) in early pregnancy.

References: Anders Hagen Jarmund et al: Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond, Frontiers in Immunology.

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